Stem cell therapy reduces Parkinson’s symptoms in mice

In what could be life-changing news for people with Parkinson's disease, Brazilian researchers have found a way of using stem cell therapy to better manage the symptoms of the disease in mice. Published in the journal Frontiers in Cellular Neuroscience, the study could lead to eventual human use of stem cell-generated neurons for Parkinson's symptoms. 

Previous studies have shown that the implantation of stem cells into the brains of mice works to combat Parkinson's symptoms, but the mice from these experiments also developed tumors due to the stem cells multiplying uncontrollably. The researchers, based at the D'OR Institute for Research and Education (IDOR) and the University of Rio de Janeiro (UFRJ), wanted to see whether these tumors could be controlled by using anti-tumor medication after the implantation of the stem cells.

Using mice modeled for Parkinson's symptoms, the researchers broke them into three groups, one that would receive stem cell implants that had been treated with the anti-tumor medication, one that would receive only the stem cell therapy, and a control group that received neither treatment. What they found was encouraging: Both of the groups of mice that received the stem cell treatment had reduced Parkinson's symptoms, and those who were given the cells that had been pre-treated with the anti-tumor drug developed no tumors over the course of the experiment.

Lead author Stevens Rehen wrote in the study's conclusion, "This simple strategy of shortly exposing pluripotent stem cells to an anti-cancer drug turned the transplant safer, by eliminating the risk of tumor formation."

To investigate stem cell therapy options for aging longevity and other purposes, contact the Longevity Centres of America today.